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Graphene Oxide Covalently Grafted Fe2[email protected]2 Nanoparticles for Epirubicin Loading and Releasing

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In this work, stable superparamagnetic core–shell Fe2[email protected]2 nanoparticles were prepared by “one pot” chemical reduction of ferric ion salts with NaBH4 and silica shell coating in the presence of citric acid stabilizer. The X-ray (XRD) and selection of electron diffraction (SAED) revealed that Fe2[email protected]2 nanoparticles were chiefly composed of silica shell and Fe2B with a small amount of α-Fe. Then, graphene oxide (GO) was assembled onto core–shell Fe2[email protected]2 nanoparticles for Epirubicin (EPI) loading and releasing, and the adsorption isotherm of EPI on Fe2[email protected]2@GO was analyzed. The results showed, the adsorption process includes two steps, due to the ππ stacking effect of EPI on the Fe2[email protected]2@GO. The EPI loading efficiency of the magnetic nanoparticles was as high as 90%, while the EPI-loaded core–shell Fe2[email protected]2 nanoparticles showed an obvious pH controlled drug release behavior, and showed lower cumulative release rate when pH is 7.4 than that when pH is 5.7. The prepared nanoparticles demonstrated potential application in killing tumor cells while minimizing the toxicity to normal tissues.
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Keywords: Core–Shell [email protected] Magnetic Nanoparticle; Epirubicin Loading and Releasing; [email protected]@GO

Document Type: Research Article

Affiliations: 1: School of Chemistry and Molecular Engineering, East China University of Science & Technology, Shanghai 200237, China 2: State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130012, China 3: Analysis Test Center, Yangzhou University, Yangzhou 225009, China 4: Department of Materials Science and Engineering, University of Delaware, DE 19716, USA

Publication date: April 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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