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Content loaded within last 14 days Regenerative Effect of Resorbable Scaffold Embedded Boron-Nitride/Hydroxyapatite Nanoparticles in Rat Parietal Bone

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BN has important roles in several physiological events, including bone growth and immune system. New infection-free cranioplasty and has an osteogenic activities material that are compatible with tissue are being developed. We aimed in our study to examine whether different combinations of Boron-nitride/Hydroxyapatite are embedded into the scaffold in the treatment of calvarial defects. 200 adult female Sprague-Dawley rats divided into 10 equal groups. Osteotomy was made by trepan drill in 8 mm diameter. The scaffolds were placed in the rats and were left to recovery for 2 months. During the experiment, CT scans were taken from the calvarial areas of the rats in the 2nd, 4th and 8th weeks. Significant healing was observed in defect diameters in 2.5% BN+10% HA, 2.5% BN and 5% BN+10% HA, respectively. After 8 weeks, it was seen that the amounts of OPN, BMP-2, RunX2 and ALP mRNA expression significantly decreased in 2.5% BN+10% HA, 2.5% BN, 5% BN+10% HA and 5% BN groups. It was shown that bone recovery was at the best grade in the groups, which contained 2.5% BN and 2.5% BN+10% HA when compared to the other groups. BN is a very promising agent that will be used in reconstructive surgery for the treatment of calvarial bone defects.
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Keywords: BN; Bone; Boron-Nitride; Defect; Skull

Document Type: Research Article

Affiliations: 1: Department of Pharmacology, Kafkas University Faculty of Medicine 36210 Kars, Turkey 2: Department of Pharmacology, Faculty of Medicine, Ataturk University 25240 Erzurum-Turkey 3: Nanotechnology Research and Application Center, Sabanci University, Istanbul, 34100, Turkey 4: Department of Material Engineering, Faculty of Engineering, Anadolu University, 26150 Eskisehir, Turkey 5: Department of Moleculary Science and Biotechnology, Faculty of Science, Yeditepe University, 34100 Istanbul, Turkey 6: Department of Radiology, Faculty of Medicine, Ataturk University 25240 Erzurum-Turkey

Publication date: February 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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