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Synthesis and Characterization of a Novel Near-Infrared Fluorescent Probe for Living Cells Imaging

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Currently, optical probes with near-infrared (NIR) fluorescence are of great interest in chemical biology. In the present study, we designed and synthesized a novel NIR fluorescent probe, IR789. IR789 has high selectivity and sensitivity for living cells imaging. The stronger excitation and emission characteristics suggested its dominant optical properties over ICG. IR789 also showed a high affinity and inconspicuous cytotoxicity at the cellular level. The results of fluorescent image in living A549 cells (human lung adenocarcinoma epithelial cell line) further demonstrated its potential applications for biomedical diagnosis in biological systems utilization of nanotechnology.
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Keywords: Fluorescent Probe; Human Lung Adenocarcinoma Epithelial Cell Line; IR789; Indocyanine Green; Near-Infrared Fluorescence Imaging

Document Type: Research Article

Affiliations: 1: School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China 2: Emergency Department, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China 3: College of Life Sciences, Binzhou University, Binzhou 256600, China

Publication date: February 1, 2020

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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