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Mechanical Strength, Surface Properties, Cytocompatibility and Antibacterial Activity of Nano Zinc-Magnesium Silicate/Polyetheretherketone Biocomposites

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In order to improve the biological activity and antibacterial properties of polyetheretherketone (PK) as bone implants, nano zinc-magnesium silicate (nZMS)/PK bioactive composites (nZPC) were fabricated. The results revealed that the mechanical properties, surface roughness and hydrophilicity of the nZPC gradually increased with nZMS content, in which nZPC with 50 w% of nZMS (50nZPC) exhibited the best properties. In addition, incorporation of nZMS into PK significantly improved the apatite mineralization ability of nZPC, which depended on nZMS content. Moreover, the attachment, proliferation and differentiation of MC3T3-E1 cells on nZPC were significantly enhanced with increasing nZMS content. Furthermore, after incorporation of nZMS into PK, the nZPC could inhibit the growth of Escherichia coli (E. coli), in which 50nZPC revealed the best antibacterial activity. The results suggested that 50nZMPC with good bioactivity, cytocompatibility and antibacterial activity might be a promising candidate as an implant for bone repair and anti-infection.
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Keywords: Antibacterial Activity; Cytocompatibility; Nano Zinc-Magnesium Silicate; Polyetheretherketone

Document Type: Research Article

Affiliations: 1: Department of Orthopedics, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huai’an, 223300, Jiangsu Province, China 2: Centre of Polymer Systems, University Institute, Tomas Bata University in Zlin, Tr T Bati 5678, Zlin 76001, Zlin, Czech Republic 3: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China

Publication date: December 1, 2019

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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