Superparamagnetic Iron Oxide Nanoparticles (SPIONs) have attracted a great deal of research attention due to their enormous possibilities of utilisation in different bioapplications such as magnetic particle imaging, drug delivery, hyperthermia or magnetic bio-detection. The purpose
of this review is to critically analyze the methods for synthesis of SPIONs reported at the literature taking into account their suitability in molecular recognition applications by means of their conjugation to biomolecules. In this work, we have summarized the main synthesis routes, and
controlled agglomeration methods for enhancement of sensitivity at molecular recognition events. This includes conventional chemical precipitation methods, thermal decomposition, microemulsions, or microfluidic synthesis, and the main strategies for the preparation of nanocomposites or SPIONs
nanoclusters, such as polymer or silica cross-linking reactions, entrapment in nanovesicles or flower-like structures through the appropriate use of different metals to get synergetic properties for the total nanoarquitecture. Since most of the actual applications in biomedicine require their
conjugation to biomolecules, an analysis of the Strengths, Weaknesses, Opportunities and Threats of these methods was carried out for the first time, with a view to highlight the best routes for a given application at biomolecular recognition.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
Document Type: Research Article
Departamento de Física & IUTA, Universidad de Oviedo, Campus de Viesques, 33204 Gijón, Spain
Departamento de Química Física y Analítica, Universidad de Oviedo, C/Julián Clavería 8, 33006 Oviedo, Spain
August 1, 2019
More about this publication?
Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Terms & Conditions
- Ingenta Connect is not responsible for the content or availability of external websites