@article {Sharma:2019:1533-4880:915,
title = "Citrus junos Fruit Extract Facilitates Anti-Adipogenic Activity of Garcinia cambogia Extract in 3T3-L1 Adipocytes by Reducing Oxidative Stress",
journal = "Journal of Nanoscience and Nanotechnology",
parent_itemid = "infobike://asp/jnn",
publishercode ="asp",
year = "2019",
volume = "19",
number = "2",
publication date ="2019-02-01T00:00:00",
pages = "915-921",
itemtype = "ARTICLE",
issn = "1533-4880",
eissn = "1533-4899",
url = "https://www.ingentaconnect.com/content/asp/jnn/2019/00000019/00000002/art00042",
doi = "doi:10.1166/jnn.2019.15915",
keyword = "Reactive Oxygen Species, Citrus junos, Lipid Accumulation, 3T3-L1",
author = "Sharma, Kushal and Adhikari, Deepak and Kim, Hyun Jung and Oh, Sung-Hwa and Oak, Min-Ho and Yi, Eunyoung",
abstract = "Obesity is a metabolic disorder associated with chronic oxidative stress and inflammation. Recruitment of inflammatory cells to adipose tissue and subsequent production of a large amount of reactive oxygen species (ROS) facilitates adipocyte differentiation and promotes lipid accumulation.
The removal of ROS with anti-oxidants appeared an effective strategy against lipid accumulation. Here, we chose Citrus junos, a good dietary source of anti-oxidants and tested the anti-adipogenic potential of Citrus junos extract (CE). CE effectively suppressed the ROS production
and lipid accumulation in H2O2-stimulated 3T3-L1 cells. CE also inhibited the expression of CEBP- and PPAR-, the transcription regulators of adipocyte differentiation. These data suggest that CE might suppress the adipocyte differentiation
through ROS scavenging action. Also, CE and Garcinia cambogia extract (GE) appeared act additively in reducing ROS and in inhibiting lipid accumulation. It implied a potential usefulness of this combination in the management of obesity related disorders.",
}