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Reduction-Responsive Release of Solid Lipid Nanoparticle Composed of Stearic Acid and Cystamine

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A reduction-responsive solid lipid nanoparticles (SLNs) were prepared by an emulsification evaporation and solidification method using stearic acid (SA) and cystamine as constituting materials. The mean hydrodynamic diameter of the SLN decreased from 510.6 nm to 117.0 nm, as the molar ratio of SA to cystamine increased from 1:0 to 1:1. On the TEM photo, negatively stained SLNs were found as black circles and the diameter was tens to hundreds of nanometer. According to the EDS analysis, the sulfur content of SLN was found to be 1.19% (w/w) to 3.62% (w/w), depending on the molar ratio of SA to cystamine (1:0.125 to 1:1) employed in the preparation. According to the differential scanning calorimetric analysis, the melting point decreased gradually from about 52 °C to 50 °C as the molar ratio of SA to cystamine increased from 1:0 to 1:1. Even if cystamine (a disulfide compound) was contained in SLN, the release degree at 25 °C was not significantly affected by dithiothreitol (DTT, a reducing agent). Whereas, the release degree at 37 °C and 52 °C was significantly suppressed by DTT when cystamine was contained in SLN, possibly because cystamine would be more readily reduced to aminoethanethiols in the SLN matrix at the higher temperatures.
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Keywords: Cystamine; Melting Point; Reduction; Release; Solid Lipid Nanoparticle

Document Type: Research Article

Affiliations: Department of Medical Biomaterials Engineering, College of Biomedical Science and Institute of Bioscience and Biotechnology, Kangwon National University, 192-1, Hyoja 2 dong, Chuncheon, Kangwon-do 20-701, Republic of Korea

Publication date: May 1, 2018

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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