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Ultrasensitive Detection of Oligonucleotides: Single-Walled Carbon Nanotube Transistor Assembled by DNA Block Copolymer

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Biosensors, which harness the unique specific binding properties of biomaterials such as proteis, are increasingly recognized as a powerful tool for chemical sensing. In this context, the detection of nucleic acids DNA and RNA will take on ever more importance for screening as the fields of genomics and diagnostics advance. The same properties that allow molecular recognition–strong, specific non-covalent interactions–also enable bottom-up assembly of sensing architectures. Here, we take advantage of such interactions for the self-assembly of field-effect transistors from semiconducting single-walled carbon nanotubes selectively dispersed by DNA-block-copolymers and anchored to the electrodes through DNA hybridization. These transistors can sensitively detect the hybridization of complementary target DNA strands through transduction of the chemical recognition event into electrical doping, achieving an analyte sensitivity of 10 fM. Such ultra-sensitive electrical-based detection removes the need for DNA amplification and offers a new route to nucleic acids diagnostics.

Keywords: 10 fM Limit of Detection; Ambipolar FETs; Biosensors; CNT Devices

Document Type: Research Article

Affiliations: 1: Department of Chemical Engineering, Ajou University, Suwon 16499, Republic of Korea 2: Zernike Institute for Advanced Materials, University of Groningen, 9747 AG, Groningen, The Netherlands 3: Department of Biomedical Sciences, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea 4: Department of Chemistry, Pukyong National University, Busan 48513, Republic of Korea

Publication date: August 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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