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A Note on the Role of Spatial Scale in Imaging Collagen Hydrogels

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Fibrillar collagen hydrogels have been used widely as bioactive scaffolds for multiple applications in biomedical and tissue engineering. The physical functions of collagen fibrils are regulated by their underlying microstructure—represented by fibrillar density and orientation. The extent to which characterization techniques are used for imaging collagen fibrillar networks has significantly reduced the usefulness of published data for biomedical engineers. This short communication explains the level of uncertainty surrounding fibrillar orientation measurements. It is discussed how a correlation between the orientation of collagen fibrils and normal distribution function can provide a robust baseline for comparative research in imaging collagen.
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Keywords: Collagen; Dispersion; Second Harmonic Generation; Size Dependency

Document Type: Research Article

Affiliations: Department of Mining and Materials Engineering, McGill University, Montreal, QC, H3A 0C5, Canada

Publication date: July 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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