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Solid Lipid Nanoparticles Loaded with Antitumor Lipophilic Prodrugs Aimed to Glioblastoma Treatment: Preliminary Studies on Cultured Cells

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The treatment of glioblastoma multiforme (GBM), the most malignant human glioma, is hampered mainly by the polyclonality and by the invasion modalities of the tumor, by the cell resistance to therapy and by the blood-brain barrier (BBB) presence. Solid lipid nanoparticles (SLN) have been recently proposed as vehicles for anticancer drugs for GBM treatment, according to their ability to enhance drug uptake by BBB endothelial cells and to evade cell resistance mechanisms. Moreover, their surface can be engineered in order to be selectively directed towards BBB. Nevertheless, many anticancer drugs are too hydrophilic to be loaded in the lipid matrix. In this experimental work an innovative formulation technology, named coacervation, was employed for SLN preparation, while anticancer drug loading was obtained through a lipophilic prodrug synthetic approach. Preliminary aims were the assessment of the cytotoxicity of the obtained formulations against GBM cultures obtained from human primary tumors, and of their potentiality in BBB overcoming by using cellular models. The encouraging results obtained with various anticancer drugs will pulse further studies in animal models in order to investigate their in vivo fate.

Keywords: Anticancer Drugs Lipophilic Prodrugs; BBB; Coacervation; Cytotoxicity; Glioblastoma; SLN

Document Type: Research Article

Affiliations: 1: Research Center, Policlinico di Monza Foundation, Vercelli, Italy 2: Università degli Studi di Torino—Dipartimento di Scienza e Tecnologia del Farmaco, Torino 3: Università degli Studi di Torino—Dipartimento di Neuroscienze, Torino 4: Università degli Studi di Torino—Dipartimento di Scienze Veterinarie, Grugliasco 5: Università degli Studi di Torino—Dipartimento di Oncologia, Orbassano

Publication date: May 1, 2017

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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