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A Facile Surface Modification of Polyethylenimine-Stabilized Gold Nanoparticles and Their Enhanced Cytotoxicity

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For biomedical applications, in particular for in vivo applications, surface modification of nanoparticles is prerequisite. We report a simple route to ligand exchange of polyethylenimine (PEI)-stabilized Au nanoparticles to polyethylene glycol or polyvinylpyrrolidone, simply by adjusting the pH of solution. Transmission electron microscopy and UV-vis analyses revealed that there was no size change or aggregation during the ligand exchange reaction. We also found that decrease of the electrostatic attraction between PEI and the Au nanoparticles by increasing pH of the solution is important for the ligand exchange reaction. PEG-stabilized Au nanoparticles also exhibited the enhanced biocompatibility and reduced cytotoxicity (apoptotic activity) in human dermal fibroblasts compared with PEI-stabilized Au nanoparticle.
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Keywords: Cytotoxicity; Gold Nanoparticles; Ligand Exchange; Polytheyleneimine; Surface Modification

Document Type: Research Article

Affiliations: 1: Department of Chemical Engineering, Kyung Hee University, Yongin 446-701, Korea 2: School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Korea

Publication date: July 1, 2016

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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