Long Non-Coding RNAs and Prostate Cancer
A new class of transcripts, long non-coding RNAs (lncRNAs), has been recently found to be pervasively transcribed in the genome. These mRNA-like molecules, which lack significant protein-coding capacity, once thought to be a part of the dark matter, now have been implicated in a wide range of biological functions through diverse and as yet poorly understood molecular mechanisms. Multiple facets of evidence increasingly link mutations and dysregulations of lncRNAs to prostate cancer (PCA). Despite some recent insights into how lncRNAs function in such diverse cellular processes as regulation of gene expression and assembly of cellular structures, by and large, the key questions regarding lncRNA mechanisms remain to be answered. In this review, we analysis recent advances in understanding the biological functions of lncRNAs especially in PCA and propose avenues of investigation that may lead to fundamental new insights into their functions and mechanisms of action. Finally, as numerous lncRNAs are dysregulated and disorders in PCA, we also discuss potential roles for these molecules in PCA and hope that can be used in clinic by nanotechnology.
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Document Type: Research Article
Publication date: May 1, 2013
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- Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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