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Preparation and Characterization of Nano-Hydroxyapatite Nanomaterials for Liver Cancer Cell Treatment

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Nano-hydroxyapatite was synthesized by means of the hydrothermal treatment. The effects of nanohydroxyapatite material on the behaviour of G2 liver cancer cells were explored. About 50% of cell viability was lost in nHAp material treated cells at 200 °[email protected] h, followed by ∼30% in nHAp treated cells at 100 °[email protected] h. Compared with control, nHAp material treated cells at 200 °[email protected] h showed 60% and nHAp material treated cells at 100 °[email protected] h showed 15% morphological change. Moreover, 50% of cell death was observed at 24 h incubation with nHAp material treated at 200 °[email protected] h cells and 56% cell death at 48 h incubation and hence alters and disturbs the growth of cancer cells. In contrast, the nHAp material treated at 100 °[email protected] h protects the cells and could be used for liver cancer cell treatment.
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Document Type: Research Article

Publication date: March 1, 2013

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  • Journal for Nanoscience and Nanotechnology (JNN) is an international and multidisciplinary peer-reviewed journal with a wide-ranging coverage, consolidating research activities in all areas of nanoscience and nanotechnology into a single and unique reference source. JNN is the first cross-disciplinary journal to publish original full research articles, rapid communications of important new scientific and technological findings, timely state-of-the-art reviews with author's photo and short biography, and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and medicine.
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