Evaluation on Cytotoxicity and Genotoxicity of the L-Glutamic Acid Coated Iron Oxide Nanoparticles
To evaluate the cytotoxicity and genotoxicity of L-glutamic acid (Glu) coated Fe2O3 nanoparticles (hereafter refer as [email protected]) on Chinese Hamster Lung (CHL) cells using Trypan blue dye exclusion assay, Oxidative stress markers, Comet assay and micronucleus (MN) assay. Results showed a low cytotoxicity with an IC50 was 254.739 μg/ml 36 h post incubation period in CHL cells. Furthermore, Cell redox status is slightly disturbed: [email protected] exposure cause reactive oxygen species production, glutathione depletion and inactivation of some antioxidant enzymes: glutathione reduc-tase, superoxide dismutase, but not catalase. Moreover, no significant genotoxic response was observed in CHL cells over concentration ranges from 8 to 128 μg/mL for all exposure time periods. The results suggest that the [email protected] show biocompatibility In Vitro.
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Document Type: Research Article
Publication date: March 1, 2012
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