@article {Liu:2009:1533-4880:1198,
title = "Electrical-Sensitive Nanoparticle Composed of Chitosan and Tetraethyl Orthosilicate for Controlled Drug Release",
journal = "Journal of Nanoscience and Nanotechnology",
parent_itemid = "infobike://asp/jnn",
publishercode ="asp",
year = "2009",
volume = "9",
number = "2",
publication date ="2009-02-01T00:00:00",
pages = "1198-1203",
itemtype = "ARTICLE",
issn = "1533-4880",
eissn = "1533-4899",
url = "https://www.ingentaconnect.com/content/asp/jnn/2009/00000009/00000002/art00119",
doi = "doi:10.1166/jnn.2009.C119",
keyword = "ELECTRIC-STIMULI, NANOPARTICLE, POLYELECTROLYTE",
author = "Liu, Kun-Ho and Liu, Ting-Yu and Liu, Dean-Mo and Chen, San-Yuan",
abstract = "In the present study, the nanoparticles with size of 50130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-controlled release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency
as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism.
The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off."",
}