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Effect of Oleuropein on Glycemia in Dogs

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Natural polyphenols have long attracted growing interest for their beneficial effects on human health. Oleuropein, present in olive leaves and oil drupes, is one of the main phenolic compounds recently studied. Among the various nutraceutical properties of oleuropein, its hypoglycemic power has found wide interest in human medicine. At present, the potential hypoglycemic effect of oleuropein in dogs has not yet been evaluated. The aim of this study was to evaluate the effect of oleuropein on glycemia in dogs. The study was carried out on 10 clinically healthy dogs. Subjects received for two weeks a nutritional supplement containing oleuropein at the dose of 2 mg/kg body wt/day. Prior to administration of the supplement and at the end of each week the postprandial glycemic curve was evaluated after administration of a carbohydrate-only meal (6 g starch/kg body wt). For the evaluation of the glycemic curve a rapid test (Pic GlucoTest) on capillary blood was used. Glycemia was evaluated on a fasting basis (T0) and after the meal at 30 (T30), 60 (T60), 90 (T90) and 120 (T120) minutes. Despite the short period of oleuropein administration, the results showed low blood glucose values and the tendency towards early stabilization even in the absence of statistical significance. Furthermore, a statistical significant effect of breed was found. These results certainly stimulate to continue the investigations with higher dosages and/or with prolonged administration in diabetic dogs as well.


Document Type: Research Article

Publication date: June 1, 2018

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  • Journal of Nutritional Ecology and Food Research is an international journal which publishes peer-reviewed articles on food production and consumption, with regard to health, environment, society and economy. The scope is thus broad, articles being focused on significant novel research in human and animal nutrition, food science and technology, food marketing and transportation. In addition, articles on food and identity, agriculture and sustainability, are also welcome. The journal only publishes novel, high quality review papers, original research papers, short communications, concerning all aspects of food and nutrition. It is journal policy to publish special issues on topical and emergent subjects of nutrition and food research or related areas.
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