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A Computational Model to Study the Concentrations of DNA, mRNA and Proteins in a Growing Cell

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Modelling of gene expression is the process which the theoretical information from a gene, in the synthesis of functional gene product, can be expressed in the mathematical way. In this paper, the differential equation model is developed and the effect of change of the concentration of DNA, mRNA and protein is discussed mathematically. In the present model, it is assumed that the replication, transcription, reverse transcription and translation taking place in the cell. The consumption or degradation of DNA is taking place in the cell due to transcription and the degradation of mRNA is considered as the form of reverse transcription and translation in the cell but there is no degradation of protein in the cell. The results have been used to obtain temporal concentration profiles of DNA, mRNA and protein for TJK16 strain and the analytical solution is carried out for the initial value problem.
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Keywords: DIFFERENTIAL EQUATION MODEL; DNA; MRNA; PROTEIN; TJK16

Document Type: Research Article

Publication date: September 1, 2015

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  • Journal of Medical Imaging and Health Informatics (JMIHI) is a medium to disseminate novel experimental and theoretical research results in the field of biomedicine, biology, clinical, rehabilitation engineering, medical image processing, bio-computing, D2H2, and other health related areas.
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