Intrinsic Electric Field as a Control Mechanism of Intracellular Transport Along Microtubules
Cytoskeletal transport involves a combination of microtubules with kinesin and dynein motors as well as the actin filaments with myosin motors. Such transport is essential for the creation and maintenance of cell organization; failed transport is implicated in neurodegeneration and other diseases. The general question of the mechanism of the transport direction regulation is still an open issue. We offer a new appealing mechanism for this regulation. It is based on the role of cellular intrinsic electrical fields as the switch tools in association with active impact of microtubules through nonlinear excitations of their flexible C-termini.
Keywords: ATP; DYNEIN; FERROELECTRIC; GTP; INTRINSIC CELLULAR ELECTRIC FIELDS; KINESIN; KINK; MICROTUBULE
Document Type: Research Article
Publication date: 01 March 2009
- Journal of Computational and Theoretical Nanoscience is an international peer-reviewed journal with a wide-ranging coverage, consolidates research activities in all aspects of computational and theoretical nanoscience into a single reference source. This journal offers scientists and engineers peer-reviewed research papers in all aspects of computational and theoretical nanoscience and nanotechnology in chemistry, physics, materials science, engineering and biology to publish original full papers and timely state-of-the-art reviews and short communications encompassing the fundamental and applied research.
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