Provider: Ingenta Connect
Database: Ingenta Connect
Content: application/x-research-info-systems
TY - ABST
AU - Mazzaferro, Silvia
AU - Bouchemal, Kawthar
AU - Maksimenko, Andrey
AU - Skanji, Rym
AU - Opolon, Paule
AU - Ponchel, Gilles
TI - Reduced Intestinal Toxicity of Docetaxel Loaded Into Mucoadhesive Nanoparticles, in Mouse Xenograft Model
JO - Journal of Colloid Science and Biotechnology
PY - 2012-12-01T00:00:00///
VL - 1
IS - 2
SP - 210
EP - 217
KW - MUCOADHESION
KW - LDH
KW - INTESTINAL TOXICITY
KW - PIBCA NANOPARTICLES
KW - HISTOLOGICAL ANALYSIS
KW - DOCETAXEL
KW - USSING CHAMBER
N2 - The present study demonstrated that the local intestinal toxicity of docetaxel (Dtx) was low when encapsulated in mucoadhesive nanoparticles composed of methyl-β-cyclodextrin (Me-β-CD)/poly(isobutylcyanoacrylate) coated with thiolated chitosan. The experiments
were carried out using intestinal specimens collected from mice with a subcutaneous tumor at an advanced stage in order to obtain challenging pathological conditions. Surprisingly, both Dtx-loaded nanoparticles and unloaded-nanoparticles when administered orally induced a lower level of the
intestinal and the colonic inflammations and ulcerations compared to intravenous (i.v) Dtx injection. The small intestine and the colon sections showed a preserved architecture, normal thickness of the mucosa, and normal viability. Furthermore, Dtx-loaded nanoparticles and unloaded-nanoparticles
allowed decreasing the release of lactate dehydrogenase (LDH) enzyme of 22% and 43% respectively in comparison with the i.v. Taxotere® administration. These results indicated clearly that: (i) Me-CD/poly(isobutylcyanoacrylate) nanoparticles coated with thiolated chitosan reduced
the local intestinal toxicity of Dtx, (ii) unloaded mucoadhesive nanoparticles had a protective effect allowing the preservation of intestinal integrity in mouse xenograft model.
UR - https://www.ingentaconnect.com/content/asp/jcsb/2012/00000001/00000002/art00007
M3 - doi:10.1166/jcsb.2012.1022
UR - https://doi.org/10.1166/jcsb.2012.1022
ER -