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MicroRNA-506 Up-Regulation Inhibits Growth and Invasion in Non-Small Cell Lung Cancer Cells by Possibly Targeting Sphingosine Kinase 1

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Increasing evidence has confirmed that dysregulation of microRNAs (miRNAs) contributes to the proliferation and invasion of human cancers. Previous studied have shown that dysregulation of miR-506 is in numerous cancers. However, the roles of miR-506 in human non-small cell lung cancer (NSCLC) have not been well clarified. Therefore, this study was to investigate the biological functions and molecular mechanisms of miR-506 in NSCLC cell lines, discussing whether it could be a therapeutic biomarker of NSCLC in the future. In our study, we found that miR-506 was down-regulated in NSCLC cell lines and tissues. Moreover, the low level of miR-506 was associated with increased expression of Sphingosine kinase 1 (SPHK1) in NSCLC cells. Up-regulation of miR-506 significantly inhibited cell proliferation, invasion, MMP-2 and -9 expressions of NSCLC cells. Bioinformatics analysis predicted that the SPHK1 was a potential target of miR-506. Further study by luciferase reporter assay demonstrated that miR-506 could directly target SPHK1. Overexpression of SPHK1 in NSCLC cells transfected with miR-506 mimic partially reversed the inhibitory of miR-506. In conclusion, miR-506 inhibited cell proliferation and invasion in NSCLC cells by down-regulation of SPHK1, and that downregulation of SPHK1 was essential for the miR-506-inhibited cell invasion and in NSCLC cells.
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Keywords: INVASION; MICRORNA-506; NON-SMALL CELL LUNG CANCER; PROLIFERATION; SPHINGOSINE KINASE 1

Document Type: Research Article

Publication date: September 1, 2015

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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