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Chitosan Modified Alginate-Polyurethane Scaffold for Skeletal Muscle Tissue Engineering

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A biodegradable scaffold in tissue engineering serves as a temporary skeleton to accommodate and stimulate new tissue growth. In this study, the morphology and characterization of three-dimensional (3D) micro-porous scaffold fabricated by freeze drying produced from biodegradable chitosan (CS), Sodium alginate (SA) and Polyurethane (PU) foam for skeletal muscle graft substitute was used. This study includes the morphology of CS scaffolds, the chemical characterization and porosity, water absorption properties and in vitro enzymatic degradation of the 3D micro-porous structures. Water absorption would reduce along with the decrease of CS scaffolds' pore diameter. In vitro enzymatic degradation results showed that the disintegration rate of CS scaffolds increases as the processing time increases. Cell proliferation on the CS/SA and CS/SA/PU scaffold was found to be faster than on a pure CS scaffold. Cell proliferation in blended scaffold was higher than in pure CS when checked in vitro using L6 cell line. This study suggested that novel ternary CS/SA/PU scaffolds potentially serve as an improved alternative to CS scaffolds for skeletal muscle tissue engineering.

Keywords: ALGINATE; BIODEGRADATION; CHITOSAN; POLYURETHANE; TISSUE ENGINEERING

Document Type: Research Article

Publication date: August 1, 2015

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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