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Model-Based Evaluation of Reactive Hyperemia Using Strain-Gauge Plethysmography and Log-Linearized Viscoelastic Indices

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Endothelial dysfunction is an initial stage in atherosclerosis, and is associated with cardiovascular disease. In this study, the authors proposed a new method to evaluate response in reactive hyperemia with viscoelastic indices including those of stiffness and viscosity measured using straingauge plethysmography on a beat-to-beat basis. In order to investigate the validity of the proposed method, assessment was performed to ascertain whether response in reactive hyperemia differed between younger and older subjects. A group of ten healthy male volunteers consisting of seven younger (22.4 ± 1.3 years; range 22–24) and three older (53.3 ± 4.9 years; range 50–59) subjects was recruited for measurement of viscoelastic parameters and pulse wave velocity (PWV). There were significant differences in stiffness and viscosity in time-series representations of values measured after cuff deflation (30–120 seconds) between the younger and older subjects (p < 0.05). However, the measured PWV values showed no significant difference between the two groups (P = 0.22). These findings suggest that the proposed viscoelastic indices represent arterial mechanical property changes that may be derived from flow-mediated vasodilation. The proposed strain-gauge plethysmography technique is applicable to non-invasive assessment of endothelial function as an alternative low-cost approach with less dependence on intravascular pressure.


Document Type: Research Article

Publication date: April 1, 2015

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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