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Fabrication of Electrospun Scaffolds Incorporating an Amazonian Therapeutic Oil from the Copaifera Species for Wound Care Applications

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Electrospinning provides an efficient and versatile method to produce novel biomaterials from a range of natural and synthetic polymers, which show excellent biocompatibility due to the very high surface area-to-volume ratio. In addition, the incorporation of bioactive compounds into biodegradable polymers, such as poly(lactic-co-glycolic acid) (PLGA) allows the fabrication of drug releasing bioactive scaffolds for potential use in novel wound care applications. Native to the tropical region of Latin America, Copaiba oil is extracted from material from the Copaifera species. The oil is a FDA approved compound known for its wound healing, anti-inflammatory, analgesics, antifungal and antimicrobial functions. In this study, microfiber non-woven scaffolds were fabricated via electrospinning solutions of PLGA containing copaiba oil. Tests of cell growth with lung fibroblasts reported a strong affinity of the fibroblasts and the biomaterial.
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Keywords: COPAIBA; ELECTROSPINNING; FIBROBLASTS; POLY(LACTIC-CO-GLYCOLIC ACID); SKIN REGENERATION; TISSUE ENGINEERING

Document Type: Research Article

Publication date: 01 March 2014

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  • Journal of Biomaterials and Tissue Engineering (JBT) is an international peer-reviewed journal that covers all aspects of biomaterials, tissue engineering and regenerative medicine. The journal focuses on the broad spectrum of research topics including all types of biomaterials, their properties, bioimplants and medical devices, biofilms, bioimaging, BioMEMS/NEMS, biosensors, fibers, tissue scaffolds, tissue engineering and modeling, artificial organs, tissue interfaces, interactions between biomaterials, blood, cells, tissues, and organs, regenerative medicine and clinical performance.
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