Skip to main content
padlock icon - secure page this page is secure

Silica-Coated Gold Nanorods with High Photothermal Efficiency and Biocompatibility as a Contrast Agent for In Vitro Terahertz Imaging

Buy Article:

$106.64 + tax (Refund Policy)

The application of terahertz imaging in biomedical diagnostics is limited by the poor imaging contrast due to the strong absorption of terahertz waves by water molecules in the living body. To resolve this problem, gold nanorods (GNRs) have been considered as a possible contrast agent. However, the conventional preparation of GNRs requires using cetyltrimethylammonium bromide (CTAB) as a stabilizing surfactant, which is toxic to animals at high exposures. In this work, a modified seed-mediated growth method was proposed to synthesize silica-coated GNRs, which exhibited better stability and biocompatibility and the same cellular uptake efficiency as compared to those of uncoated GNRs. Moreover, silica-coated GNRs showed higher photothermal efficiency caused by the localized surface plasmon resonance that increased the terahertz reflection amplitude. In particular, the in vitro terahertz imaging of prostate cancer cells demonstrated noticeably higher contrast when silica-coated GNRs were used as a contrast agent. Hence, this study suggests a stable, biocompatible, and efficient contrast-enhancing agent for terahertz imaging, which can expand the scope of its clinical applications.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: May 1, 2019

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more