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Using Plant Virus Based Nanorods to Modulate the Differentiation of Human Bone Marrow Stem Cells

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Tobacco mosaic virus (TMV) is a protypical nanorod-shaped bioparticles that has been used as a building block to construct a variety of self-assembled nanomaterials for different biomedical applications, including drug delivery, in vivo imaging, tumor immunotherapy and tissue engineering. In this work, the roles of TMV and its mutant TMV-RGD1 nanoparticles on the differentiation of human bone marrow stem cells (hBMSCs), an important process in bone regeneration, were carefully investigated. We observed that cells cultured on the TMV-RGD1 nanorods coated substrate showed significantly higher levels of gene and protein expression of osteo-specific markers osteocalcin (OCN) and bone morphogenetic protein 2 (BMP2). Investigation of alkaline phosphatase (ALP) activity and calcium deposition further confirmed that the TMV-RGD1 substrate could promote the osteogenesis and induce the mineralization of hBMSCs. On the other hand, the adipogenesis was downregulated on TMV and TMV-RGD1 coated substrates. Taken together, this study demonstrates for the first time the potential of TMV-RGD1 in promoting osteogenic differentiation of hBMSCs which can lead to future applications in clinical bone engineering.
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Keywords: BIONANOPARTICLE; HUMAN BONE MESENCHYMAL STEM CELLS; MULTIVALENCY; NANOTOPOGRAPHY; OSTEOGENIC DIFFERENTIATION

Document Type: Research Article

Publication date: February 1, 2019

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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