Skip to main content
padlock icon - secure page this page is secure

Redox-Sensitive Folate-Conjugated Polymeric Nanoparticles for Combined Chemotherapy and Photothermal Therapy Against Breast Cancer

Buy Article:

$106.23 + tax (Refund Policy)

We have developed redox-sensitive folic acid-conjugated PCL-PEG-PCL (PCEP) nanoparticles for co-delivering chemotherapeutic agent doxorubicin (DOX) and imaging and hyperthermia agent indocyanine green (ICG) with simultaneous imaging and combined therapy for breast cancer. DOX and ICG were entrapped into PCEP nanoparticles through the thin-film hydration and ultrasonic dispersion. Then nanoparticles were surface decorated with folic acid ligands against FR overexpressing breast cancers. Drug-loading nanoparticles exhibited an enhanced reduction-sensitivity in the presence of 10 mM glutathione. Nanoparticle-mediated treatment had synergistic cytotoxicity against mammary cancer cells. The conjugation of folic acid improved the uptake of nanoparticles in EMT-6 breast cancer overexpressing cell lines, and the uptake efficacy of DOX was remarkably increased by the laser irradiation. Furthermore, ex vivo fluorescence imaging confirmed that folate conjugation also improved drug accumulation in tumor. Our unique FA-DINPs system has potential for combination of chemotherapy and photothermal therapy for breast cancer.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics

Keywords: CHEMOTHERAPY; DOXORUBICIN; DRUG DELIVERY SYSTEM; FOLIC ACID; INDOCYANINE GREEN; PHOTOTHERMAL THERAPY; REDOX-SENSITIVE

Document Type: Research Article

Publication date: December 1, 2018

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
X
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more