
In Vivo Dopamine Biosensor Based on Copper(I) Sulfide Functionalized Reduced Graphene Oxide Decorated Microelectrodes
A novel dopamine biosensor based on carbon fiber microelectrodes (CFMEs) modified with copper(I) sulfide functionalized nanocomposites of the reduced graphene oxide (Cu2S/RGO) has been explored for the sensitive detection of dopamine and in vivo monitoring the neurotransmitters
released by Drosophila's brain. The as-prepared Cu2S/RGO decorated microelectrodes were characterized by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS), and cyclic voltammetry (CV). Our observations demonstrate that Cu2S/RGO-CFMEs exhibited
excellent catalytic activity and high selectivity for dopamine with relatively low detection limit (24 nM), wide linear range (i.e., from 0.1–20 μM) and outstanding reproducibility. Furthermore, the as-prepared new dopamine biosensor with high sensitivity and good stability
was readily used to detect the amount of dopamine in the brain of drosophila, indicating the potential and promising application in the in vivo measurement of neurotransmitters without other electrochemical interference such as histidine, ascorbic acid, uric acid, and others.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics
Keywords: COPPER SULFIDE; CYCLIC VOLTAMMETRY; DOPAMINE; MICROELECTRODE; REDUCED GRAPHENE OXIDE
Document Type: Research Article
Publication date: July 1, 2018
- Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Terms & Conditions
- Ingenta Connect is not responsible for the content or availability of external websites