@article {Niemirowicz:2017:1550-7033:665,
title = "Pharmacokinetics and Anticancer Activity of Folic Acid-Functionalized Magnetic Nanoparticles",
journal = "Journal of Biomedical Nanotechnology",
parent_itemid = "infobike://asp/jbn",
publishercode ="asp",
year = "2017",
volume = "13",
number = "6",
publication date ="2017-06-01T00:00:00",
pages = "665-677",
itemtype = "ARTICLE",
issn = "1550-7033",
url = "https://www.ingentaconnect.com/content/asp/jbn/2017/00000013/00000006/art00004",
doi = "doi:10.1166/jbn.2017.2363",
keyword = "HOMING LIGANDS, BIODISTRIBUTION, COLORECTAL CANCER, MAGNETIC NANOPARTICLES, THERANOSTIC",
author = "Niemirowicz, Katarzyna and Car, Halina and Sadowska, Anna and Wtek, Marzena and Krowski, Rafa and Cechowska-Pasko, Marzanna and Wilczewska, Agnieszka Z. and Mystkowska, Joanna and Kasacka, Irena and Torres, Anna and Bucki, Robert",
abstract = "The theranostic potential of functionalized magnetic nanoparticles (MNPs) generates different possibilities for their medical application, including better control of toxicity and reduction of potential side effects. Aminosilane magnetic nanoparticles (MNP@NH2) and their
folic acid derivatives (MNP@FA) labeled by N-hydroxysuccinimide ester (IRDye 800CW) were evaluated for prospective use in the design of new diagnostic and treatment tools for colorectal cancer, using the DLD-1 cell culture system and an animal model of cancer xenograft. In cell culture,
MNP@FA internalization and nuclear localization were associated with decreased cell viability and increased apoptosis rate. Independent of the application method, the presence of folic acid on the MNP surface resulted in more rapid elimination from mice, without non-specific accumulation in
animal organs. Additionally, increased retention of MNP@FA, restriction of tumor growth, and Caspase-3 dependent apoptosis were observed in the mouse xenograft model of colorectal cancer. Rapid and preferential uptake of MNP@FA by cancer cells associated with their ability to eliminate and
prevent cancer cell growth (reduction of tumor mass) indicates their potential for targeted cancer therapy with lower toxicity.",
}