@article {Xin:2015:1550-7033:1153,
title = "Evaluation of rMETase-Loaded Stealth PLGA/Liposomes Modified with Anti-CAGE scFV for Treatment of Gastric Carcinoma",
journal = "Journal of Biomedical Nanotechnology",
parent_itemid = "infobike://asp/jbn",
publishercode ="asp",
year = "2015",
volume = "11",
number = "7",
publication date ="2015-07-01T00:00:00",
pages = "1153-1161",
itemtype = "ARTICLE",
issn = "1550-7033",
url = "https://www.ingentaconnect.com/content/asp/jbn/2015/00000011/00000007/art00004",
doi = "doi:10.1166/jbn.2015.2062",
keyword = "SCFV, STEALTH LIPOSOMES, DRUG THERAPY, TARGETING, RECOMBINANT METHIONINASE",
author = "Xin, Lin and Cao, Jia-Qing and Liu, Chuan and Zeng, Fei and Cheng, Hua and Hu, Xiao-Yun and Shao, Jiang-Hua",
abstract = "Stealth PLGA/Liposome nanoparticles (NPs) modified with tumor-targeting single-chain antibody fragment (scFV-P/L) for systemic delivery of recombinant methioninase (rMETase) for gastric cancer were prepared. The morphologies and therapeutic effects of rMETase-loaded scFV-P/L (scFV-rMETase-P/L)
in vitro were analyzed. Functional scFV-P/L NPs composed of PLGA, DOPC and DSPE-PEG display low cell cytoxicity in SGC-7901 cells, and has more cell uptake ability than P/L NPs. scFV-rMETase-P/L was more effective in inhibiting tumor growth in the subcutaneous gastric carcinoma tumor
model than free rMETase in solution (p < 0.05) and rMETase-loaded P/L (rMETase-P/L) (p < 0.05). Our findings collectively support the utility of scFV-targeted P/L NPs as a potentially effective drug delivery system.",
}