@article {Luo:2015:1550-7033:600,
title = "Indocyanine Green Derivative Covalently Conjugated with Gold Nanorods for Multimodal Phototherapy of Fibrosarcoma Cells",
journal = "Journal of Biomedical Nanotechnology",
parent_itemid = "infobike://asp/jbn",
publishercode ="asp",
year = "2015",
volume = "11",
number = "4",
publication date ="2015-04-01T00:00:00",
pages = "600-612",
itemtype = "ARTICLE",
issn = "1550-7033",
url = "https://www.ingentaconnect.com/content/asp/jbn/2015/00000011/00000004/art00005",
doi = "doi:10.1166/jbn.2015.1926",
keyword = "FIBROSARCOMA, PHOTOTHERMAL THERAPY, ICG, GOLD NANORODS, PHOTOCHEMICAL THERAPY, RGD-4C",
author = "Luo, Teng and Qian, Xiaoqing and Lu, Zhiyong and Shi, Yiwen and Yao, Zhirong and Chai, Xinyu and Ren, Qiushi",
abstract = "A hydrophilic indocyanine green derivative (ICG-Der-02) was covalently doped into mesoporous silica-coated gold nanorods (AuNRs/mSiO2). The self-synthesized derivative offers one carboxyl functional group on a side chain, which enables ICG-Der-02 to be covalently linked to
nanomaterials and reduces the probability of leakage/desorption of the dye. The detection of infrared luminescence around 1270 nm confirmed that 1O2 is efficiently generated by the nanocomposite (AuNRs/mSiO2-ICG-Der-02). Furthermore, a second layer of silica
was coated onto the nanocomposite, which then was conjugated with the v
integrin-targeting cyclic peptide (RGD-4C). The cell tests showed that the resulting nanoconjugate (AuNRs/mSiO2-ICG-Der-02/RGD-4C) was able to bind preferentially to HT-1080 human fibrosarcoma
cells. Due to the synergistic effect of the produced nanoconjugates, a dual-modality photothermal and photochemical therapy was successfully achieved by 808 nm irradiation. Compared to using photothermal or photochemical therapy alone, the dualmodality photothermal/photochemical therapeutic
strategy proved to be more damaging to HT-1080 cells and enhanced the effectiveness of photodestruction. Our work presents a novel approach to the multimodal treatment of fibrosarcoma and shows promise for future use in cancer theranostics.",
}