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A New Quantitative Method to Determine the Uptake of SPIONs in Animal Tissue and Its Application to Determine the Quantity of Nanoparticles in the Liver and Lung of Balb-c Mice Exposed to the SPIONs

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We propose a new method for determining the quantity of superparamagnetic iron oxide nanoparticles (Fe3O4, SPIONs) embedded in animal tissue using magnetization measurements. With this method, the smallest detectable quantity of magnetite nanoparticles in a tissue sample is ∼1 μg. We showed that this method has proved being efficient. In this study, we focused in determining the quantity of SPION confined in lung and liver tissue of mice injected with ∼13 nm magnetite superparamagnetic nanoparticles. Furthermore, the method allowed us to detect the magnetite nanoparticles present in animal tissues without letting the natural iron ions present in the tissue or blood interfere with the measurements.
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Keywords: MAGNETIC NANOPARTICLES; SPIONS QUANTIFICATION; SUPERPARAMAGNETISM

Document Type: Research Article

Publication date: January 1, 2013

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  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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