Nanotoxicity of Natural Minerals: An Emerging Area of Nanotoxicology
Nanotoxicity of two natural minerals, talc and silica were evaluated in vitro studying their effects on cell viability, LDH leakage, LPO induction, ROS production, GSH depletion, modulation of GR and GPx activities. Both mineral particles mediated their toxicity through oxidative stress. Differently, silica nanoparticles showed insignificant effect on GSH depletion. Talc nanoparticles significantly enhanced transcription and translation of TNF-&alpha which was mediated by both ERK1/2 and P38. This aspect of study on silica nanoparticles is in progress.
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Document Type: Research Article
Publication date: January 1, 2011
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- Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
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