Skip to main content
padlock icon - secure page this page is secure

Design Variations for an Aptamer-Based DNA Nanodevice

Buy Article:

$110.00 + tax (Refund Policy)

The performance of DNA nanodevices based on a thrombin-binding DNA aptamer is strongly dependent on chemical modifications and extensions of the protein-binding core sequence. We here give an overview of the influence of fluorescent labeling and extension of the aptamer device sequence on its binding properties. Sequence extension on the 5′ end as well as labeling on the 5′ or 3′ end does not significantly reduce the binding capabilities. Sequence extension on the 3′ end completely suppresses binding. This knowledge can be utilized for the construction of a doubly labeled aptamer device which can be operated as a switchable molecular beacon.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
No Metrics


Document Type: Research Article

Publication date: March 1, 2005

More about this publication?
  • Journal of Biomedical Nanotechnology (JBN) is a peer-reviewed multidisciplinary journal providing broad coverage in all research areas focused on the applications of nanotechnology in medicine, drug delivery systems, infectious disease, biomedical sciences, biotechnology, and all other related fields of life sciences.
  • Editorial Board
  • Information for Authors
  • Subscribe to this Title
  • Terms & Conditions
  • Ingenta Connect is not responsible for the content or availability of external websites
  • Access Key
  • Free content
  • Partial Free content
  • New content
  • Open access content
  • Partial Open access content
  • Subscribed content
  • Partial Subscribed content
  • Free trial content
Cookie Policy
Cookie Policy
Ingenta Connect website makes use of cookies so as to keep track of data that you have filled in. I am Happy with this Find out more