Expression of p16INK4a in Endometrioid Cancer Rat Model
Endometrioid cancer is a common gynecological malignancy in women. Endometrioid cancer model which resembles endometrioid cancer in human is needed to understand molecular carcinogenesis and the development of new therapies. Decreased expression of p16INK4a, a tumor suppressor gene,
is found in endometrioid cancer and has prognostic value. The expression of this protein in animal models has been studied to evaluate its similarity with human endometrioid cancer. Fifteen paraffin blocks of rat consist of 5 normal uterine tissues, 5 atypical hyperplasia of uterine tissues,
and 5 endometrioid cancer tissues were stained for immunohistochemistry. Expressions of p16INK4a were analyzed using IHC profiler Image-J software. The expression score of p16INK4a increased significantly in the hyperplasia group compared with the normal group (p = 0.003) and significantly
decreased in the endometrioid cancer group compared to the normal group (p = 0.01). Excessive expression of the tumor suppressor gene in the hyperplasia group is one of the cell’s mechanisms to reduce the proliferation activity. Highest expression of p16INK4a was found in hyperplasia
group and decreased to negative expression in endometrial cancer group. These patterns were similar to human endometrial cancer.
No Reference information available - sign in for access.
No Citation information available - sign in for access.
No Supplementary Data.
No Article Media
Document Type: Research Article
Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Indonesia
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia
Publication date: September 1, 2018
More about this publication?
ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
- Editorial Board
- Information for Authors
- Subscribe to this Title
- Ingenta Connect is not responsible for the content or availability of external websites