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Could Tenascin-C Be Introduced as Post-Circumcision Wound Healing Biomarker?

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In the era of personalized health, the quest for biomarker as tools of examination, of diagnosis and of follow up deemed necessary. In this study, the author analyzed the outcome of skin tissue repair dorsal-slit and laser (cauterization) through expression of tenascin-C. (TNC) is an extracellular glycoprotein expressed during embryogenesis and markedly increased in wound healing, especially in resolution phase. This study was conducted from July 2015 until May 2016 at Histology Lab FMUI and obtained ethical clearance from FMUI ethical committee no 751b/UN2.F1/ETIK/VIII/2015. Prepuces from 20 male participants (5–12 years old) were collected under signed informed consent and stained using hematoxylin-eosin staining to determine incisional margin area. Tenascin-C expression was determined by immunohistochemistry with ratio of TNC positive area and incisional margin area. Follow-up investigation was done using post-operative questionnaire and photographs to determine the status of wound healing. The conventional group showed greater TNC expression (57.28±47.56%) than cauterization group (25.36±16.44%) (p = 0.07). The mean expression of TNC in normal wound healing subjects (42.15±40.87%) is slightly more than the mean of delayed wound healing subjects (38.83±33.40%) (p = 0.872). The number of subjects with normal healing after cauterization or conventional techniques is almost identical. The data presented here suggested that higher TNC expression indicate a trend toward normal wound healing. Further study with larger sample number is required.
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Keywords: Cauterization; Circumcision; Dorsal-Slit; Tenascin-C; Wound Healing

Document Type: Research Article

Affiliations: 1: Medical Doctor International Class Program, Faculty of Medicine Universitas Indonesia (FMUI), Indonesia 2: Department of Histology, Faculty of Medicine Universitas Indonesia (FMUI), Indonesia

Publication date: September 1, 2018

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