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Epidermal Vascular Endothelial Growth Factor Improved Wound Healing of Patients with Diabetic Foot Ulcer

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Diabetic foot ulcer (DFU) is a kind of chronic vascular complications in diabetes. Wound healing in DFU is a complex process where reduced proangiogenic growth factor is an important factor. We studied angiogenesis factors which may contribute to the healing of DFU. Twenty five type 2 diabetes patients with acute DFU were treated with hospital standard procedure and closely observed for 1 month. Biopsies from wound edges were subjected to histopathology assessment and immunohistochemical staining of CD34, bFGF and VEGF. All examination was performed two times consecutively. We observed that granulation tissues developed faster at proximal site of the foot. Weak tissue VEGF was expressed before treatment. Interestingly, VEGF expression in epidermis increased significantly after patients received treatment. Increased VEGF is consistent with increased number of CD34 positive endothelial cells. These data suggest that epidermal VEGF is an important angiogenesis factor and may improve healing in acute DFU receiving standard treatment.
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Keywords: Angiogenesis; Diabetic Foot Ulcer; Vascular Endothelial Growth Factor

Document Type: Research Article

Affiliations: 1: Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia 2: Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Publication date: August 1, 2018

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