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Evaluation of In Vitro Antiurolithiatic Potential of Bridelia retusa Spreng. Bark

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Urolithisis is a very complex disease which is characterized by the formation of renal calculi in urinary track/kidney. Several physic chemical events like super saturation, nucleation, growth, aggregation and retention of dietary minerals of urine in the kidney leads to the formation of kidney stone; for this a essential need to develop a formulation which is made up of medicinal pant belong to the class of Pasanabheda plant according to ancient literature available in Ayurveda, which facilitate the repair mechanism in a natural way towards the organ. Bridelia retusa, is a well know plant of Western Ghats. Present study deals with the inhibitory effect of different fraction of methanol extract of Bridelia retusa. Nucleation of calcium oxalate crystals was estimated by the spectrophotometric assay and whereas crystal dissolution was determine by titrimetry/egg shell permeation method, hence the extract fractions exhibited inhibitory action in both of nucleation and aggregation assays to significant level.
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Keywords: Bridelia retusa; Renal Calculi; Titrimetry; Urolithiasis

Document Type: Research Article

Affiliations: Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, Karnataka, India

Publication date: March 1, 2017

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