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An Increase in the Accumulation of Adipose Tissue in Growing Male Mice Caused by Disturbances in the Sleep-Wake Cycle Following Night-Shifts

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The aim of this study was to assess the effects of circadian rhythm disturbances induced by night-shift activities on the accumulation of abdominal adipose tissue and the morphological characteristics and bone mineral density (BMD) of the trabecular bone in the fourth lumbar vertebrae (L4). Fourteen 6-week-old C57BL/6 male mice were assigned to 2 groups, namely, the normal group (NOR; n = 7) and the night-shift group (NS; n = 7). Mice in the NS group were kept under a light/dark cycle that changed every 3 days. The area of the visceral, subcutaneous, and entire abdominal adipose tissue and the structural parameters and BMD of the trabecular bone in the L4 were measured at 0 weeks and 4 weeks from images acquired by in vivo micro-computed tomography. At 4 weeks, the area of the visceral abdominal adipose tissue was significantly higher in the NOR group than in the NS group (p < 0.06). However, there were no significant differences in the accumulation of other adipose tissue or in the structural parameters and BMD of the trabecular bone in the L4 (p > 0.05). These results implied that the circadian rhythm disturbances induced by night-shift activities increased the accumulation of abdominal adipose tissue, particularly in the visceral region, and led to an increased risk of obesity in the growing mice.
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Document Type: Research Article

Publication date: August 1, 2013

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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