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Attachment of Docetaxel to Multiwalled Carbon Nanotubes for Drug Delivery Applications

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In this manuscript we report the development of multiwalled carbon nanotubes—docetaxel conjugate by covalent interaction, involving nucleophilic substitution reaction mechanism. The surface functionalization of nanotubes was carried out by enrichment of carboxylic groups with optimized oxidation treatment. The carboxyl groups were converted to acyl groups followed by covalent attachment of docetaxel to multiwalled carbon nanotubes with a cleavable ester linkage. The drug carbon nanotube conjugate was characterized by Fourier Transform Infra red, UV-Visible, Raman spectroscopy, Scanning and Transmission electron microscopy. The drug release from the conjugate was studied in vitro in phosphate buffers having pH 5, 6.8 and 7.4. It was demonstrated that conjugate showed drug release faster in acidic pH, which resembles the pH of cancerous cells, as compared to buffer of normal cell pH. This property would reduce the drug dosage thereby substantially benefit the antitumor effect and would boost significantly the applications of carbon nanotubes in the biomedicine field.
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Document Type: Research Article

Publication date: October 1, 2012

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  • ADVANCED SCIENCE LETTERS is an international peer-reviewed journal with a very wide-ranging coverage, consolidates research activities in all areas of (1) Physical Sciences, (2) Biological Sciences, (3) Mathematical Sciences, (4) Engineering, (5) Computer and Information Sciences, and (6) Geosciences to publish original short communications, full research papers and timely brief (mini) reviews with authors photo and biography encompassing the basic and applied research and current developments in educational aspects of these scientific areas.
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