Innovative Excipients and Formulation Platforms in Cosmetic Product Series for Acne (ACNOFIX^®): The Physiochemical Characteristics of Cosmeceutical Vehicle

Salicylic acid has many functions and may be used in many types of cosmetics and personal care products including anti-acne properties. The purpose of this investigation is to study the physicochemical characteristics of different formulations of salicylic acid which are used as anti-acne cosmetic products (foam, cream, lotion and wipes, commercialized under the trade name ACNOFIX^®, by InterMed). In these formulations, innovative excipients are used in order to achieve high-quality products for consumers. These innovative excipients offer advantages to the cosmeceutical vesicles. Dynamic and Electrophoretic Light Scattering Techniques were used in order to determine the size distribution and the zeta potential of the colloidal particles of these formulations. Contin and NNLS were used in order to evaluate the size and the size distribution of colloidal particles of the final formulations. These methods were used for the precise evaluation of physicochemical characteristics (size distribution) by number and by volume of hydrodynamic diameter, which indicate the exact population of colloidal particles in all studied formulations. These studies demonstrated that the colloidal particles of lotion and cream are in the micrometer range and of the foam and wipes (bulk liquid) in nanoscale, with adequate size distribution with respect to the nature of the product particles. Finally, the negative zeta potential of the particles of the cream and lotion justifies sufficiently the physicochemical stability of the final cosmeceutical formulation.