Cerasomes as Innovative Excipients in Cosmetic Product “Pregnaderm Extreme Hydration Body Cream”: A Physicochemical Study
The purpose of this investigation was to study the physicochemical characteristics of cerasomes which are used as innovative excipients in cosmetic products. Moreover, stability studies on a commercial product comprises of cerasomes, were carried out. The physicochemical characteristics of the wheat cerasomes dispersions which are part of the formula of the commercial product: “Pregnaderm extreme hydration body cream” (Intermed S.A.) were carried out during a period of three days. In addition physicochemical studies were carried out in the commercial product in order to define the role of cerasomes in its stability. Dynamic and Electrophoretic Light Scattering were used in order to determine the size distribution and the zeta potential of cerasomes in a concentration range from 0.1% w/w to 2.0% w/w. The results shown that there were not statistically significant difference in the range of concentrations studied, in terms of mean hydrodynamic diameter, polydispersity and zeta potential. The size of the colloidal particles of the emulsion was found to be in the micrometer scale and the population of these particles was quite polydisperse. The zeta-potential was found to be negative, about –55 mV, as mentioned in the literature. The stability studies showed that the mean hydrodynamic diameter increased approximately 300 nm in 3 days after reconstitution of the lyophilized powder of wheat cerasomes, at all concentrations except the concentration of 0.1% w/w. The last one is the concentration which is used in the commercial product. The presence of wheat cerasomes in the commercial product proves a challenge in terms of the moisturizing effect as well as of the improved hydration of the pregnant women's skin. In conclusion, we can state that cerasomes can provide added value to the cosmetic products offering cosmetic advantages to the final products in terms of hydration and improving their physical stability.
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Document Type: Research Article
Publication date: January 1, 2016
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