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A Unique Nanoemulsion Drug Delivery System for Azithromycin and Its Antibacterial Activity

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Azithromycin, the most prescribed second generation antibiotic is used effective against many pathogenic bacterial infections. But due to certain drawbacks in its physico-chemical properties including poor aqueous solubility and low oral bioavailability, we designed a novel cinnamon leaf essential oil based nanoemulsion system of azithromycin to improve its efficacy through oral route. Azithromycin incorporated nanoemulsion was formulated using cinnamon oil (Cinnamomum zeylanicum), tween 80 and water using sonication technique at laboratory conditions. This system produced uniform and spherical droplet diameter in the nanometer scale after a sonication period of 30 min. Also, this azithromycin incorporated system was studied for its anti-bacterial activity against Staphylococcus aureus (ATCC 25923) that demonstrated significant activity at a minimum concentration of 16 μg/ml in comparison with its conventional formulation (128 μg/ml) of azithromycin. Further, scanning electron microscopic technique signified considerable alteration in the morphology of the pathogen. The possible outcome could be due to the active component present in cinnamon oil, together with their reduced particle size.
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Document Type: Research Article

Publication date: April 1, 2014

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  • Advanced Science, Engineering and Medicine (ASEM) is a science, engineering, technical and medical journal focused on the publishing of peer-reviewed multi-disciplinary research articles dealing with all fundamental and applied research aspects in the areas of (1) Physical Sciences, (2) Engineering, (3) Biological Sciences/Health Sciences, (4) Medicine, (5) Computer and Information Sciences, (6) Mathematical Sciences, (7) Agriculture Science and Engineering, (8) Geosciences, and (9) Energy/Fuels/Environmental/Green Science and Engineering.
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