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Bacopa Monnieri Modulate Aluminum Induced Macromolecular Changes in Rat Brain: A Magnetization Transfer Contrast Brain Imaging Study

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The aim of the present study was to time coarse assessment of aluminum chloride induced macromolecular changes by in vivo magnetization transfer brain imaging and therapeutic efficacies of Bacopa monnieri (BM) have been investigated. In the present study, 100 mg/kg of AlCl3 daily was administered orally to rats and co-administered with BM (40 mg/kg) for 90 days. Significantly decreased magnetization transfer ratio (MTR) in the hippocampus of Al treated rats along with increased lipid and protein peroxidation. Ultrastructural steady also revealed that lipofuscin accumulation (a product of lipid peroxidation), demylination and disrupted nucleolar morphology in Al treated rats. B. monnieri significantly reversed Al induced morphological and biochemical changes. In conclusion, the study of the MTR profile, biochemical and ultrastructural study demonstrates in vivo the loss of neuronal lipid and proteins as evident by ultrastructural studies. This methodological approach can be applied to assessment of aluminum exposed patients to show neurodegeneration, should prove helpful to determine the degree of spontaneous and therapeutically induced regeneration and thus to validate therapeutic treatments for neuronal loss and repair.
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Keywords: ALUMINIUM; BACOPA MONNIERA; BRAIN IMAGING; DONEPEZIL; RAT BRAIN

Document Type: Research Article

Publication date: October 1, 2013

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  • This journal aims to focus specifically on the emerging new aspects of neuroprotection and neuroregeneration in the widest sense of neuroscience. American Journal of Neuroprotection and Neuroregeneration (AJNN) deals with research on all the aspects of the central nervous system: relevant CNS diseases, their processes and their modification with drugs that may have any influence and significance in experimental and clinical conditions.
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