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Synthesis of 9-Substituted Derivatives of Tert-butyl 6-(9H-purin-6-ylthio) Hexylcarbamate

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We report herein the synthesis of series of 9-substituted derivatives of tert-butyl 6-(9H-purin-6-ylthio) hexylcarbamate by the reaction of tert-butyl 6-(9H-purin-6-ylthio) hexylcarbamate with different acid chlorides using triethylamine in Dichloromethane solvent.
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Keywords: 6-MERCAPTOPURINE; ACYLATION; BOC-DEPROTECTION; DICHLOROMETHANE; TERT-BUTYL 6-(9H-PURIN-6-YLTHIO) HEXYLCARBAMATE

Document Type: Research Article

Publication date: June 1, 2013

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  • Advanced Chemistry Letters is an international multidisciplinary peer-reviewed journal covering all fundamental and applied research areas of chemical sciences including organic chemistry, inorganic chemistry, synthetic chemistry, medicinal chemistry, analytical chemistry, organometallic chemistry, nuclear chemistry, electrochemistry, atmospheric chemistry, environmental chemistry, materials chemistry, materials science, supramolecular chemistry, physical chemistry, polymer chemistry, bioinorganic chemistry, physical organic chemistry, surface chemistry, biochemistry, molecular biology, chemical biology, food chemistry, natural product chemistry, neurochemistry, pharmacology, photochemistry, photobiology, toxicology, nanoscience, nanotechnology, agrochemistry, green chemistry, marine chemistry, geochemistry, petrochemistry, radiochemistry, astrochemistry, molecular physics, chemical engineering, quantum chemistry, and theoretical and computational chemistry.
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