Anti-LGI1 Encephalitis: A Case Report of a Recently Described Disease Entity
Anti-leucine-rich glioma-inactivated protein 1 encephalitis is a rare disease characterized by autoantibodies to a secreted synaptic protein associated with the voltage-gated potassium channel complex and previously attributed to voltage-gated potassium channel antibodies. The classic
clinical presentation is limbic encephalitis with memory loss and pathognomonic faciobrachial dystonic seizures, but patients can also experience paroxysmal dizziness, as well as pain and other symptoms of peripheral nervous system involvement. We present a case of anti‐leucine-rich
glioma-inactivated protein 1 encephalitis as a review of the clinical presentation, laboratory findings, and imaging findings, and discuss prognosis with treatment. A brief review of the anti‐leucine-rich glioma-inactivated protein 1 encephalitis literature is also provided.
Keywords: AMPAR = α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; FBDS = faciobrachial dystonic seizure; LGI1 = leucine-rich glioma-inactivated protein 1; VGKC = voltage-gated potassium channel
Document Type: Research Article
Publication date: 01 June 2019
- Neurographics is the peer-reviewed, quarterly educational journal of the American Society of Neuroradiology. The journal includes review articles as well as high-yield case reports that have been solicited from society meetings, including the annual meeting of the ASNR as well as the American Society of Spine Radiology, the American Society of Pediatric Neuroradiology, the American Society of Functional Neuroradiology, and the American Society of Head and Neck Radiology meetings. Unsolicited educational review articles and case reports are also accepted for review at the discretion of the Editor-in-Chief. Submissions focusing on a pictorial approach to educational objectives are highly encouraged. The journal is open access and available online. CME credit is offered for reading review articles and completing activity evaluations through the ASNR Education Connection website: https://www.pathlms.com/asnr
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