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Free Content Anti-LGI1 Encephalitis: A Case Report of a Recently Described Disease Entity

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Anti-leucine-rich glioma-inactivated protein 1 encephalitis is a rare disease characterized by autoantibodies to a secreted synaptic protein associated with the voltage-gated potassium channel complex and previously attributed to voltage-gated potassium channel antibodies. The classic clinical presentation is limbic encephalitis with memory loss and pathognomonic faciobrachial dystonic seizures, but patients can also experience paroxysmal dizziness, as well as pain and other symptoms of peripheral nervous system involvement. We present a case of anti‐leucine-rich glioma-inactivated protein 1 encephalitis as a review of the clinical presentation, laboratory findings, and imaging findings, and discuss prognosis with treatment. A brief review of the anti‐leucine-rich glioma-inactivated protein 1 encephalitis literature is also provided.
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Keywords: AMPAR = α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; FBDS = faciobrachial dystonic seizure; LGI1 = leucine-rich glioma-inactivated protein 1; VGKC = voltage-gated potassium channel

Document Type: Research Article

Publication date: June 1, 2019

More about this publication?
  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities.

    Visit the ASNR Education Connection to view all available CME courses.

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