Overcoming “Stage” Fright: American Joint Committee on Cancer 8th Edition Pharyngeal Cancer Update
Learning Objectives: 1) Compare the American Joint Committee on Cancer 7th Edition description of T4 disease versus the 8th edition description of T2 disease for nasopharyngeal carcinoma, 2) explain the relationship between the Epstein-Barr virus and nasopharyngeal carcinoma as well as the human papillomavirus and p16+ oropharyngeal cancer, and 3) describe the impact of extranodal extension on clinical staging for cervical nodal metastasis in the setting of an unknown primary tumor, as well as for p16− oropharyngeal and hypopharyngeal cancers.
Keywords: 7th Edition = American Joint Committee on Cancer 7th Edition Cancer Staging Manual; 8th Edition = American Joint Committee on Cancer 8th Edition Cancer Staging Manual; AJCC = American Joint Committee on Cancer; EBV = Epstein-Barr virus; EBV+ = tests positive for EBV; EBV− = tests negative for EBV; ENE = extranodal extension; ENE(+) = positive for ENE; ENE(−) = negative for ENE; HPC = hypopharyngeal cancer; HPV = human papillomavirus; NPC = nasopharyngeal carcinoma; OPC = oropharyngeal squamous cell cancer; TNM = tumor, node, metastasis; cENE = clinically overt extranodal extension; p16+ = p16 overexpression; p16− = p16 underexpression or no expression; pENE = pathologically proven extranodal extension; rENE = radiologically overt extranodal extension
Document Type: Research Article
Publication date: April 1, 2019
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