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Home / Neurographics, Volume 8, Number 1

Free Content A Case of Immune Reconstitution Inflammatory‐like Syndrome in a Patient with Multiple Sclerosis Secondary to Discontinuation of Fingolimod

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Authors: Wahab, W.A.; Lee, L.; Aviv, R.

Source: Neurographics, Volume 8, Number 1, 1 February 2018, pp. 7-11(5)

Publisher: American Society of Neuroradiology

DOI: https://doi.org/10.3174/ng.9170221

We reported a case of a 41-year-old man with MS who was initially treated with fingolimod, but this treatment was stopped when the patient declined neurologically with associated lymphopenia. After medication discontinuation, the patient's clinical condition worsened dramatically. MR imaging findings demonstrated significant changes consistent with an immune reconstitution inflammatory‐like syndrome. The purpose of this case report was to increase awareness of this rarely reported condition with fingolimod withdrawal in patients with MS.

Keywords: EDSS = expanded disability status scale; IFNB = interferon B; IRIS = immune reconstitution inflammatory syndrome; JCV = John Cunningham virus; PML = progressive multifocal leukoencephalopathy

Document Type: Research Article

Publication date: 01 February 2018

More about this publication?
  • Neurographics is the peer-reviewed, quarterly educational journal of the American Society of Neuroradiology. The journal includes review articles as well as high-yield case reports that have been solicited from society meetings, including the annual meeting of the ASNR as well as the American Society of Spine Radiology, the American Society of Pediatric Neuroradiology, the American Society of Functional Neuroradiology, and the American Society of Head and Neck Radiology meetings. Unsolicited educational review articles and case reports are also accepted for review at the discretion of the Editor-in-Chief. Submissions focusing on a pictorial approach to educational objectives are highly encouraged. The journal is open access and available online. CME credit is offered for reading review articles and completing activity evaluations through the ASNR Education Connection website: https://www.pathlms.com/asnr
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