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Free Content A Case of Immune Reconstitution Inflammatory‐like Syndrome in a Patient with Multiple Sclerosis Secondary to Discontinuation of Fingolimod

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We reported a case of a 41-year-old man with MS who was initially treated with fingolimod, but this treatment was stopped when the patient declined neurologically with associated lymphopenia. After medication discontinuation, the patient's clinical condition worsened dramatically. MR imaging findings demonstrated significant changes consistent with an immune reconstitution inflammatory‐like syndrome. The purpose of this case report was to increase awareness of this rarely reported condition with fingolimod withdrawal in patients with MS.
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Keywords: EDSS = expanded disability status scale; IFNB = interferon B; IRIS = immune reconstitution inflammatory syndrome; JCV = John Cunningham virus; PML = progressive multifocal leukoencephalopathy

Document Type: Research Article

Publication date: February 1, 2018

More about this publication?
  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities.

    Visit to view all available CME courses.

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