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Free Content Imaging Characteristics, Pathologic Features, and Prognoses of the Molecular Subgroups of Medulloblastoma

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It has been well documented within the scientific literature that medulloblastoma is the most common solid malignant brain neoplasm that affects the pediatric population and, to a much lesser extent, the young adult population. However, with the emergence of recent tumor transcriptome genomics, it is now recognized that medulloblastoma is not 1 disease entity but is composed of 4 distinct molecular subgroups: wingless type, sonic hedgehog, group 3, and group 4. The purpose of this article was to describe the age distribution, radiologic features, histologic characteristics, and important prognostic information as determined by the unique molecular expression of the different subgroups.

Learning Objective: To review the clinical findings, imaging characteristics, and prognoses of medulloblastoma as determined by the molecular subgroup genomics.
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Keywords: CNS = central nervous system; CT = computed tomography; FLAIR = fluid-attenuated inversion recovery; MB = medulloblastoma; MR = magnetic resonance; SHH = sonic hedgehog; T1WI = T1-weighted imaging; T2WI = T2-weighted imaging; WNT = wingless type

Document Type: Research Article

Publication date: 01 November 2017

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  • Neurographics is the peer-reviewed, bimonthly educational journal of the American Society of Neuroradiology. The journal comprises articles selected from material presented at the ASNR Annual Meeting. Neurographics also publishes other high-quality submissions that are primarily educational and have a high emphasis on a pictorial approach. Neurographics offers CME credit for reading review articles and completing quiz-based self-assessment activities. CME credit for review articles may be claimed up to 3 years after an article's publication date. Visit https://members.asnr.org/webcast/content/course_list.asp?src=Neurographics to view all available CME courses.
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